TBHP-Promoted Trifluoromethyl-difluoromethylthiolation of Unactivated Alkenes with CF3SO2Na and PhSO2SCF2H

A TBHP-promoted trifluoromethyl-difluoromethylthiolation of alkenes was reported. Langlois’ reagent was used as a stable and inexpensive trifluoromethyl source. In the presence of TBHP, the trifluoromethyl radical generated reacted with alkenes, achieving a new alkyl radical, which could be trapped by PhSO2SCF2H, forming C–C and C–S bonds in one step and incorporating trifluoromethyl and difluoromethylthio groups. The mild conditions and broad functional group tolerance endowed the reaction with great potential in the field of pharmaceuticals and agrochemicals.