Neuroprotective and neuritogenic activities of LBA-derived compounds on mesencephalic DA neurons.

aCompounds used at 100 nM concentration. bNumber of TH+ neurons per well as a percentage of untreated cultures expressed as the mean±SEM of at least three independent experiments performed in triplicate. cNeurite length per neuron as a percentage of untreated neurons measured on at least 100 neurons per condition using an image analyser (Neurite Outgrowth, Explora Nova, France) and expressed as the mean±SEM of three independent experiments performed in triplicate. dNon-determined. eRelated values obtained at 10 nM because of a weak toxicity observed at 100 nM. f◃ = cyclopropyl. Statistical analysis was performed by one-way ANOVA followed by Bonferroni's post hoc test (P<0.001, reported in text).