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Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation

ChEBI2016-07-01 更新2026-07-12 收录

免疫代谢

巨噬细胞炎症

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-82043 数据链接链接失效反馈

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Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation

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创建时间：

2016-07-01

细胞信号传导

免疫代谢

Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWAT).

NIAID Data Ecosystem80

Table_2_Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses.docx

免疫代谢

动脉粥样硬化

Macrophages are critical components of atherosclerotic lesions and their pro- and anti-inflammatory responses influence atherogenesis. Type-I interferons (IFNs) are cytokines that play an essential ro

NIAID Data Ecosystem50

Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes

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色氨酸代谢

Exhaustive exercise can cause a transient depression of immune function. Data indicate significant effects of immune activation cascades on the biochemistry of monoamines and amino acids such as trypt

Figshare2016-05-04 更新20

Pro-survival Lipid Sphingosine-1-Phosphate Metabolically Reprograms T cell to Limit its Anti-Tumor Activity

免疫代谢

T细胞功能调控

Sphingosine 1-phosphate (S1P), a pro-tumor survival bioactive lysophospholipid, generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via transducing S1P receptor 1 (

NIAID Data Ecosystem50

DataSheet_1_Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.zip

免疫代谢

PD-1联合治疗

IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows s

NIAID Data Ecosystem30

Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation

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