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The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

Alliance of Genome Resources2026-08-01 收录

寿命调控基因

FOXO信号通路

数据链接：

https://www.wormbase.org/resources/analysis/Microarray_Study.WBPaper00040184.ce.mr 数据链接链接失效反馈

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The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

应用场景：

寿命调控基因

线粒体能量代谢

Organismic aging is known to be controlled by genetic and environmental traits. Pathways involved in the control of cellular metabolism play a crucial role. Previously, we identified a role of PaCLPP,

NIAID Data Ecosystem40

Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells

卵巢癌转移机制

FOXO信号通路

Forkhead box M1 (FOXM1) is a proliferation-associated transcription factor essential for cell cycle progression. Numerous studies have documented that FOXM1 has multiple functions in tumorigenesis and

NIAID Data Ecosystem30

YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway. YTHDF2 inhibits gastric cancer cell growth by regulating FOXC2 signaling pathway

胃癌YTHDF2机制

FOXO信号通路

We found that YTHDF2 has lower expression in GC tissues and GC cells, and promotes the growth, migration and invasion of GC cells. In addition, the analysis of clinical data found that the expression

NIAID Data Ecosystem20

Additional file 8: of A positive feed-forward loop between LncRNA-URRCC and EGFL7/P-AKT/FOXO3 signaling promotes proliferation and metastasis of clear cell renal cell carcinoma

透明细胞肾细胞癌

FOXO信号通路

Figure S3. A: Heatmaps of dysregulated mRNAs expression between sh-control and sh-URRCC groups in the treated A498 cells. B: Volcano plots of the differentially expressed mRNAs. Green and red spots re

NIAID Data Ecosystem30

Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability

寿命调控基因

衰老机制研究

Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development

NIAID Data Ecosystem30

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

资源简介：

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