Systematic simulation of the interactions of Pleckstrin homology domains with membranes: dataset

Pleckstrin homology (PH) domains can recruit proteins to membranes by recognition of phosphatidylinositol phosphate (PIP) lipids. Several family members are linked to diseases including cancer. In Le Huray et al., "Systematic simulation of the interactions of Pleckstrin homology domains with membranes", Science Advances, 2022, we report the systematic simulation of the interactions of 100 mammalian PH domains with PIP-containing membranes. This dataset contains raw coarse-grained molecular dynamics (CG MD) simulation data for all 100 individual PH domains.