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Supplementary Material for: Improved Synthesis of ADAM10 Inhibitor GI254023X
Background: The metalloproteinases ADAM10 and ADAM17 are involved in various diseases: neurodegeneration, cancer and inflammation. Objective: The inhibition of these proteases is a promising target in
NIAID Data Ecosystem110
Synthesis of Rovafovir Etalafenamide (Part IV): Evolution of the Synthetic Process to the Fluorinated Nucleoside Fragment
Fluorinated nucleoside 1 is a key starting material in the synthesis of rovafovir etalafenamide (2), a novel nucleotide reverse transcriptase inhibitor under development at Gilead Sciences for the tre
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Palladium-Catalyzed Denitrogenative Suzuki Coupling of Benzothiatriazine Dioxides for Bi(hetero)aryl-2-sulfonamides
A palladium-catalyzed denitrogenative Suzuki coupling of N-alkyl benzothiatriazine dioxides with (hetero)aryl boronic acids as well as potassium trifluoroborates is reported, affording a variety of 1,
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Osimertinib_Based高效替代合成方案数据
本数据集包含奥希替尼（Osimertinib）的高效替代合成方案相关数据，涉及对经典合成工艺的参数改进，包括溶剂、温度、试剂和反应时间等调整，建立了成本效益高且环境友好的合成方法，提升了反应效率和产率。
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Multivariate Optimization Applied to the Synthesis of Meglumine Antimoniate with Low Levels of Trivalent Antimony
Meglumine antimoniate (MA) is a pentavalent antimony (SbV) drug recommended for the treatment of leishmaniasis. It is known that the trivalent antimony (SbIII) present as a residue in MA contributes t
Figshare2021-08-01 更新80
