Additional file 9: Table S8. of DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas

CpG sites which are present or absent from the hypomethylation signature comparisons between the test tumour set, published normal brain controls and published tumour sets. The 311 CpG sites were compared to published normal controls and tumour sets, and the data represented as heatmaps in Additional file 3: Figures S13-S16. Some of the CpG sites were not represented in the comparison datasets; therefore the lists of present CpG sites are shown. The 311 CpG sites are ordered from low to high methylation in the pilocytic astrocytomas. Normal brain controls (1_Cerebellum [Lambert et al, Acta Neuropathologica 126:291-301, 2013]; Cerebral cortex [Guintivano et al, Epigenetics 8:290-302, 2013]); paediatric low-grade astrocytomas (2_validation tumour set 2; 3_[Lambert et al, Acta Neuropathologica 126:291-301, 2013]); adult low-grade astrocytomas (4_TCGA); paediatric and adult high-grade astrocytomas (5_[Sturm et al, Cancer Cell 22:425-437, 2012]), medulloblastomas (6_ [Schwalbe et al, Acta Neuropathologica 126:943-946, 2013]; Ependymomas (7_GSE45353 [Mack et al, Nature 506:445-450, 2014]) and foetal brain during development (8_GSE58885 [Spiers et al, Genome Research 25:338-352, 2015]). (XLSX 320 kb)