Gut Microbiota-Proline Axis Drives HFpEF Through Fibroblast Ferroptosis

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiometabolic disorder closely associated with systemic metabolic dysregulation. In this study, plasma samples were collected from C57BL/6J mice subjected to a high-fat diet–induced HFpEF model, with or without intervention, and analyzed using untargeted metabolomics to characterize disease-associated metabolic alterations. This dataset aims to provide insights into plasma metabolic signatures and mechanisms underlying HFpEF.