Cellular senescence is an irreversible cell growth arrest state linked to loss of tissue function and aging in mammals. The cellular transition from proliferation to senescence is marked by increased

干细胞与再生医学数据中心2022-02-20 更新130

Towards understanding the biological drivers of cellular ageing

细胞衰老

蛋白质组学

Human ageing is associated with gradual loss of tissue and organ function, with consequent frailty and illness leading to poor quality of later life for many older people. It is thought to result from

CESSDA2025-06-12 更新80

Autophagy drives fibroblast senescence through MTORC2 regulation

自噬

细胞衰老

Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to

DataCite Commons2024-02-07 更新130

Set 1_S1_molecule

肾脏疾病

细胞衰老

Renal artery stenosis (RAS) engenders stenotic-kidney ischemia, dysfunction, and injury, but whether these are mediated by cellular senescence has not been elucidated. Using INK-ATTAC transgenic mice,

DataCite Commons2020-09-24 更新80

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

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