FKBP12-FRB in Complex with Compound 12
收藏Protein Data Bank Japan2023-10-25 更新2026-04-19 收录
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https://pdbj.org/mine/summary/8er7
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FKBP12-FRB in Complex with Compound 12 Descriptor: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-5,10,21-trimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... Authors: Tomlinson, A.C.A, Yano, J.K. Deposit date: 2022-10-11 Release date: 2022-12-28 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.07 Å) Cite: Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
创建时间：
2022-10-11
