Crystal structure of the human METTL3-METTL14 complex bound to Compound 22 (UZH2)
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Crystal structure of the human METTL3-METTL14 complex bound to Compound 22 (UZH2) Descriptor: 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Bedi, R.K, Dolbois, A, Caflisch, A. Deposit date: 2021-03-30 Release date: 2021-09-01 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64, 2021
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2021-03-30
