Model of the regulatory networks involving BfmRS in P. aeruginosa.

The lines show the interaction between the players: arrow, activation; hammerheads, repression; solid line, a direct influence or direct connection; dotted line, a putative or indirect connection. The question mark (“?”) denotes a yet-unidentified factor (factors) required for triggering the kinase or phosphatase activity of BfmS. QteE reduces LasR protein stability [80]. QteE also blocks RhlR accumulation, and this effect is independent of QteE's action on LasR [80]. Inactivation of RpoS causes elevated levels of rhlI (but not rhlR) transcription [81]. See text for details. OM, outer membrane. IM, inner membrane. AcP, acetyl phosphate.