Transcriptomic and Proteomic Analyses of Sclera in Lens-Induced Myopic Guinea Pigs

To explore the potential biomarkers and signal pathways in the process of axial elongation, namely in the scleral remodeling and thinning. Overall design: A myopia guinea pig model was established using male guinea pigs aged 2–3 weeks, which underwent bilateral lens-induced myopization (LIM) (study group) or were left untreated (control group). Five eyes from both the control group and the LIM group were selected for RNA sequencing.