Regions identified in the regression analysis.

Center-of-mass coordinates are in the MNI152 (LPI) standard and structure labels are from the Talairach & Tournoux atlas. RL: Right-Left, AP: Anterior-Posterior, IS: Inferior-Superior. STG: Superior Temporal Gyrus, IFG: Inferior Frontal Gyrus, AI: Anterior Insula. BA: Brodmann Area. Crossover point refers to the location on the x-axis (years of use or weeks of abstinence) where the regression (solid) line for the CD users intersects with the mean of the control participants (dashed line). Term refers to the term of interest in the regression model (years of use or weeks of abstinence) from which the clusters were derived. Polarity refers to the sign (positive or negative) of the regression coefficients from which the cluster was generated.