High Multidrug-resistance in Urinary Tract Infections in a Tertiary Hospital, Kathmandu, Nepal

This dataset is used in the following research paper.

ABSTRACT

Setting

Tribhuvan
University Teaching Tertiary Care Hospital, Kathmandu, Nepal, May-October 2019.

Objective

Among
adult urine samples undergoing culture and drug sensitivity test to 1)describe the
bacteriological profile, 2) identify the antimicrobial resistance (AMR) pattern
and 3) find the demographic characteristics associated with the presence of
bacterial growth and multidrug-resistance (MDR).

Design

A hospital based cross-sectional study using routine
laboratory records.

Results

Among 11,776 urine samples, 16% were
culture-positive, predominantly caused by E.
coli (62%). We found high prevalence
of resistance to at least one antibiotic (84%) and MDR (54%). Resistance to
commonly used antibiotics for UTIs such as ceftazidime, levofloxacin, cefepime
and ampicillin was high. Patients ≥60 years of
age were more likely to have culture positivity (aPR-1.6, 95% CI-1.4-1.7).Patients
with age≥45 years (45-59 years: aPR-1.5, 95% CI-1.3-1.7; ≥60 years: aPR-1.4,
95% CI-1.2-1.6), male sex (aPR-1.3, 95% CI-1.2-1.5) and from inpatient setting
(aPR-1.4, 95% CI-1.2-1.7) had significantly higher prevalence of MDR.

Conclusion

Urine samples from a tertiary hospital showed high
prevalence of E. coli and MDR resistance
to routinely used antibiotics especially among inpatients. Regular surveillance
and application of updated antibiograms are crucial to monitor the AMR situation
in Nepal.