Temozolomide produces DNA damage in the form of O6-methylguanine in mouse dsDNA

Using mouse leukemic cell line as a model system, it was shown that temozolomide produces DNA damage in the form of O6-methylguanine (Taverna et al. 1992).

以小鼠白血病细胞系作为模型系统，研究表明，替莫唑胺能够以O6-甲基鸟嘌呤（Taverna等，1992年）的形式产生DNA损伤。