Impact of high-molecular weight hyaluronic acid on the gene expression of rabbit Achilles tenocytes in vitro

For three rabbit donors (denoted as R5, R8, and R11 in the Excel sheet), we present the impact of high-molecular weight hyaluronic acid (HA; Mw = 1.01 – 1.80 MDa) daily supplementation to Achilles tenocytes in vitro at time points 3 days, 7 days, and 14 days against the control which received no HA, but had otherwise the same conditions. Gene expression of target genes Biglycan, Decorin, Aggrecan, Collagen 1A1, Collagen 1A2, Collagen 3, LOX, IL-6, TNF-alpha, PAR-2, ALOX-15, Tenascin-C, Tenomodulin, Mohawk, alpha-SMA, TIMP 1, MMP 2, MMP 9, and ki67 are presented; the data were normalized to gene expression of corresponding cell culture without HA supplementation.