Fumarate hydratase (FH) mutations cause hereditary leiomyomatosis and renal cell cancer (HLRCC). We have conditionally inactivated the murine ortholog (Fh1) in renal tubular epithelial cells in order

NIAID Data Ecosystem50

PKD1 mutation perturbs morphogenesis in tubular epithelial organoids derived from human pluripotent stem cells

肾病模型

器官干细胞研究

Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal genetic disease, with most patients carrying mutations in PKD1. The main feature is the formation of bilateral renal cysts

NIAID Data Ecosystem20

The Database of Predictive Targets of miRNA let-7b.zip

miRNA靶标预测

纤维化研究

We filtered let-7b binding sites in the 3'UTRs of transcripts encoding proteins involved in fibrogenesis in Mø using online RNA databases. Briefly, we intersected the top 100 most reliable target gene

DataCite Commons2025-05-01 更新70

EGAS00001003324-sc-2020-02-20T14:26:33Z - samples

纤维化研究

吸烟相关突变分析

Sequencing of LCM-derived microbiopsies from explanted lung from pulmonary fibrosis patient. Goal to assess the mutational burden, spectrum, and clonal dynamics within the tissue. Deep sampling throug

NIAID Data Ecosystem40

Murine Kidney Tissue: Unilateral ureteral obstructed mice vs. Sham control

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