Eukaryotic IRE1 mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease mo
We report systematical profiling of translation efficiency in stress conditions of NIH3T3 cells. In this study, we pharmacologically induced ER stress by treatment of thapsigargin (THAP). Ribo-seq and
Ire1 is an endoplasmic reticulum (ER)-located transmembrane protein that triggers the unfolded protein response. I recently noticed that Ire1 is activated not only in response to ER accumulation of un
This dataset contains data used to generate panels 1C and 1D for GRP94, Hsp90 and Hsp40 in a preprint manuscript from the Misteli Lab at the National Cancer Institute/NIH. Title: Activation of endopla