Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages
收藏PubMed Central2000-05-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC103313/
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资源简介：
A triester method for the synthesis of deoxynucleoside phosphorodithioate dimers is described. The phosphorodithioate linkage is introduced using a new dithiophosphorylating reagent DPSE-SP(S)Cl(2) where DPSE = 2-diphenylmethylsilylethyl. This group is removed quickly using tetra-butylammonium fluoride leading to the quantitative formation of phosphorodithioate diesters uncontaminated with the corresponding phosphorothioates. The utility of this group is demonstrated by the synthesis of a pentadecathymidylic acid, [T(PS(2))T(PO(2))](7)T, which contains alternating phosphorodithioate/phosphate diester internucleotide linkages.
提供机构：
Oxford University Press
创建时间：
2000-05-01
