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One-Pot Synthesis of Enantiopure Pyrrolopiperazines

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NIAID Data Ecosystem2026-03-12 收录
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A simple one-pot protocol for the synthesis of fused pyrrolopiperazines with a complete diastereoselectivity has been developed. This novel methodology combined the Ugi reaction with a spontaneous enamine alkylation on a multicomponent domino reaction, starting from nonprotected diamines and arylglyoxals.

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2020-10-14
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