Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia
收藏Figshare2016-05-04 更新2026-04-29 收录
下载链接：
https://figshare.com/articles/dataset/Caveolin-1_Expression_Ameliorates_Nephrotic_Damage_in_a_Rabbit_Model_of_Cholesterol-Induced_Hypercholesterolemia/3214654
下载链接
链接失效反馈官方服务：
资源简介：
Caveolin-1 (CAV-1) participates in regulating vesicular transport, signal transduction, tumor progression, and cholesterol homeostasis. In the present study, we tested the hypothesis that CAV-1 improves dyslipidemia, inhibits cyclophilin A (CypA)- mediated ROS production, prevents mitochondrial compensatory action and attenuates oxidative stress responses in cholesterol-induced hypercholesterolemia. To determine the role of CAV-1 in mediating oxidative and antioxidative as well as cholesterol homeostasis, hypercholesterolemic rabbits were intravenously administered antenapedia-CAV-1 (AP-CAV-1) peptide for 2 wk. AP-CAV-1 enhanced CAV-1 expression by ˃15%, inhibited CypA expression by ˃50% (P
创建时间：
2016-05-04
