Diagnostic miniarray of childhood acute lymphoblastic leukemia (ALL)

We developed and validated a diagnostic miniarray to recognize different subtypes of ALL. We analyzed blindly the gene expression profiling of 17 patients: 10 ALL-B, 5 ALL-T and 2 MLL/AF4. This miniarray was able to assign all samples to the correct class. We compared the transcription profiles of the leukemic samples by miniarray competitive hybridisation against an arbitrary total RNA reference prepared from normal human bone marrow. ALL-B patients: GSM50368, GSM50369, GSM50370, GSM50371, GSM50372, GSM50373, GSM50374, GSM50375, GSM50376, GSM50377 ALL-T patients: GSM50379, GSM50380, GSM50381, GSM50382, GSM50383 ALL-B patients with the specific chromosomal aberration MLL/AF4: GSM50384, GSM50385 Keywords = Acute lymphoblastic leukemia Keywords = human bone marrow Keywords = transcriptional profiling Keywords = miniarray Reference: Haematologica 2005;90:890-898 Keywords: ordered