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Dissection of FUS domains involved in regulation of SnRNP70 gene expression

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE136663
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To identify FUS regulated genes and its dependency of snRNP70, the gene expression profiles in neurons expressing the Gly-rich domain deleted FUS mutant coupled with Snrnp70 gene knock down were analyzed. Mouse ES cell derived neurons were infected with lentivirus encoding FLAG-tagged Gly-rich domain deleted FUS, shRNA for Snrnp70 gene or both, and analysed the gene expression by RNA-seq.
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2020-10-22
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