Functional analysis of <i>PIP</i> co-modulated genes.

List of the statistically relevant top twenty of over-represented biological functions. Distinct analyses were performed using the IPA tool (version 4.0) for up- and down-regulated genes. For each function, the computed p-values are reported as well as the total number of genes. A p-value for a given process is computed using a one-side right-tailed Fisher exact test (α = 0.05) by considering the total number of up- or down-regulated genes from L235 and the number of genes that are known to be associated with that process in the IPA knowledge base. As a function may be divided in several sub-functions (for instance, the functions interphase, S phase and G1 phase and G0/G1 phase refer to the unique cell cycle function), the statistical results are displayed as an interval of p-values reflecting the range computed for each sub-function. The biological processes are ranked according to the p-value of up-regulated genes. The p-value appear in bold if the upper limit of the interval is lower than 1e−10.