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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor XMD11-50

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Protein Data Bank Japan2023-10-04 更新2026-03-21 收录
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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor XMD11-50 Descriptor: 1,2-ETHANEDIOL, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4 Authors: Xu, X, Blacklow, S.C. Deposit date: 2017-06-24 Release date: 2018-07-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.172 Å) Cite: Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13, 2018
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2017-06-24
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