Biomarker discovery in childhood asthma: a pilot study of serum metabolite analysis for IgE-dependent allergy

This dataset contains experimental data supporting the publication “Biomarker Discovery in Childhood Asthma: A Pilot Study of Serum Metabolite Analysis for IgE-Dependent Allergy”. The study was funded by grant no. 2021/43/O/NZ5/00480 from the National Science Centre, PolandThe purpose of the study was to compare metabolite concentrations in serum samples between 13 children with asthma and IgE-dependent allergy and 10 without asthma and IgE-dependent allergy, aged between 6 months and 5 years.In the study of the 188 metabolites, 131 were determined in the samples and additionally, 48 sums and ratios of metabolites were calculated. Significant differences were found for the 6 metabolites of sphingolipids and glycerophospholipids and the ratio of serotonin synthesis.The dataset provides comprehensive evidence that serum metabolite concentrations differ between children under five with asthma and IgE-dependent allergy, and children under five without asthma or IgE-dependent allergy. A multiclassifier integrating PC 40:4 and the serotonin synthesis ratio is a promising biomarker for diagnosing childhood asthma accompanied by IgE-dependent allergy.