The transcriptomic changes induced by NREP downregulation in HepG2 cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
To evaluate the global transcriptomic changes induced by Neuronal Regeneration Related Protein (NREP) downregulation, we employed RNA-sequencing in HepG2 cells lacking NREP. Enriched pathway analyses of upregulated genes revealed pathways involved in cholesterol synthesis, fatty acid metabolism, NAFLD and PI3K-250 AKT signaling. In contrast, enriched downregulated genes included those for membrane trafficking, non-sense mediated decay, glucagon signaling, and cell-cycle. Differentially expressed genes included HMGCR (cholesterol synthesis) and TGFBR1 (TGF-β signaling and fibrosis).
提供机构：
Joslin Diabetes Center
创建时间：
2022-02-20
