Premature activation of immune transcription programs in autoimmune-predisposed mouse embryonic stem cells and blastocysts

To study the underlying mechanism of autoimmunity predisposition in autoimmune-prone mouse strains, we characterize embryonic stem cells derived from various mouse strains. Overall design: We performed ChIP-Seq analysis to determine the transcriptional differences between embryonic stem cells derived from auto-immune prone mouse strains. NOD:autoimmune-prone