HR estimates and their 95% CIs from multivariate Cox proportional hazard models for both the primary and secondary outcome in 66,147 patients on cART with a suppressed viral load.

aTime-dependent covariate.bLast viral load prior to starting cART or highest viral load recorded between episodes.cOther: at least one protease inhibitor (PI) and one non-nucleoside reverse-transcriptase inhibitor (NNRTI), at least two PIs (other than ritonavir) but no NNRTI; any therapy including integrase or fusion inhibitors.dTime-dependent covariate. A HR