Mature NOTCH heterodimer traffics to the plasma membrane

Mature NOTCH translocates from the Golgi to plasma membrane. In Caenorhabditis elegans, a Golgi membrane protein sel-9, a homolog of mammalian TMED2, acts as a quality controller and prevents misfolded lin-12, a NOTCH homolog, to reach the cell surface.

成熟的NOTCH蛋白从高尔基体转移到质膜。在秀丽隐杆线虫中，高尔基体膜蛋白sel-9，哺乳动物TMED2的同源物，充当质量控制器，防止错误折叠的lin-12（NOTCH同源物）到达细胞表面。