Differential gene expression in 17<i>syn</i>⁺-, 17ΔN/H-, m2kb-S-, and 17-37-infected skin <i>in vivo</i>.

Differential gene expression between any two viruses out of 17syn+ (n = 4), 17ΔN/H (n = 3), 17-37 (n = 3), and m2kb-S (n = 3) in infected skin xenografts was calculated using DESeq2 on 3SEQ data. For any gene, a positive log2-fold change indicates an increase in the first virus over the other, whereas a negative value indicates a decrease. An adjusted p value (padj) of <0.05 indicates a significant result (yellow colour). 3SEQ10 and 3SEQ11 are not included in the comparisons because they are located within the region that is deleted in the 17ΔN/H genome. Raw counts are given for all samples, including those not used for differential gene expression analysis: the infected explants (ex vivo), mock infections, and bystanders. Codes E1-3 for explants and G5, 6, 7, and 11 for xenografts were used to indicate individual skin donors. (XLSX)