Supplementary Material for: Full-Spectrum Pachychoroid Manifestation in One Eye: A Case Report

Introduction:
The pachychoroid spectrum refers to a group of chorioretinal disorders including pachychoroid pigment epitheliopathy (PPE), pachychoroid neovasculopathy (PNV), polypoidal choroidal vasculopathy (PCV), and central serous chorioretinopathy (CSC). These conditions are thought to represent progressive stages, beginning with subclinical RPE changes in PPE, advancing to serous retinal detachment in CSC, followed by choroidal neovascularization in PNV, and culminating in aneurysmal dilation of vessels in PCV. We present a rare case of the pachychoroid spectrum in which lesions in all four stages were simultaneously observed in a single, fovea-sparing eye.
Case presentation:
An 85-year-old man presented with a one-month history of a visual disturbance in his left eye. Examination revealed all four stages of pachychoroid disease in the same eye: choroidal neovascular membrane (CNV) with subretinal hemorrhage (pachychoroid neovascularization, PNV), multiple retinal pigment epithelium (RPE) defects (pachychoroid pigment epitheliopathy, PPE), and findings consistent with central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). He was treated with a combination of anti-VEGF injections and focal laser therapy with the lesions stabilizing after 2 years.
Conclusion:
Although it has features similar to age-related macular degeneration, pachychoroid spectrum is a distinct disease entity, with a slower onset and greater response to initial therapy. It may necessitate therapies otherwise not used for other causes of neovascularization like focal laser treatment and verteporforin photodynamic therapy (vPDT). It is a unique pathologic process presenting with varying stages/lesions that have distinct morphological features but are thought to be a part of the same spectrum.