Palladium-Catalyzed Synthesis of 3‑Acylated Indoles Involving Oxidative Cross-Coupling of Indoles with α‑Amino Carbonyl Compounds

A new
and selective C–N bond oxidative cleavage method to
3-acylated indoles by Pd-catalyzed oxidative cross coupling of indoles
with α-amino carbonyl compounds has been developed; moreover,
one-pot synthesis of 3-acylated indoles from 2-ethynylanilines and
α-amino carbonyl compounds has also been established. Importantly,
the products 3-acylated indoles can be used to construct polyheterocyclic
compound, which can be employed as efficient probes for Hg2+ and Fe3+.