Decreased miR-4512 levels in monocytes and macrophages of individuals with systemic lupus erythematosus contribute to innate immune activation and neutrophil NETosis by targeting TLR4 and CXCL2 [RNA-seq]

Peripheral blood mononuclear cells from SLE patients (n = 5) and healthy controls (n = 5) were used for miRNA–mRNA co-sequencing to detect miRNAs related to immune abnormalities associated with SLE. mRNA sequencing was performed on peripheral blood mononuclear cells (PBMCs) from patients with SLE (n=5) and healthy controls