Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ChIP-Seq]

To model and characterize the chromatin regulatory landscape of the very first developmental cell fates, we made use of three previously derived and well-characterized Trophoblast Stem Cell (TSCs), Embryonic Stem Cell (ESC) and Extra Embryonic Stem Cell lines (XENs) We performed ChIP-seq for H3k27ac to map the putative active enhancers and promoters in ESC, TSC, XEN and EPISC Characterization of active enhancers and promoters with H3k27ac ChiP-seq for all cell types.