Global gene transcription analysis in Streptomyces coelicolor strains with modification of satKR genes.. Global gene transcription analysis in Streptomyces coelicolor strains with modification of satKR genes.

We addressed the transcriptional changes in strains with mutations of satKR (sco3390-3389) genes to elucidate which genes are engaged in restoration of sporulation in non-sporulating Streptomyces coelicolor PS04 strain. Our experiments show that SatR can regulate growth and spore formation in Streptomyces and its activity is independent to DNA supercoiling.