Screening data for: A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

To identify compounds that modulate squalene monooxygenase (SM) stability, screening of FDA-approved drug library was performed with HEK293 cells stably expressing SM-emerald luciferase fusion protein. For experimental details, see the accompanying article.

The data is a table with the following columns:
position, [ROW].[COLUMN].[PLATE ID];
name, name of compounds;
conc, concentration of the compounds in µM;
type, types of the treatment (conotrol "ctrl" or "library");
plate, plate id (number);
row, row number (A to H) within 96-well plates;
column, column number (1 to 12) within 96-well plates;
luc_10, luminescence data for 10 µM treatment screen;
luc_1, luminescence data for 1 µM treatment screen;
nluc_10, luminecence data for 10 µM treatment screen, normalized in a plate-wise manner;
nluc_1, luminecence data for 1 µM treatment screen, normalized in a plate-wise manner;
rsn_10, robust signal-to-noise ratio (robust Z score) for 10 µM screen;
rsn_1, robust signal-to-noise ratio (robust Z score) for 1 µM screen.