Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?

The genetic dissection of reproductive barriers between diverging lineages provides enticing clues into the origin of species. One strategy uses linkage analysis in experimental crosses to identify genomic locations involved in phenotypes that mediate reproductive isolation. A second framework searches for genomic regions that show reduced rates of exchange across natural hybrid zones. It is often assumed that these approaches will point to the same loci, but this assumption is rarely tested. In this perspective, we discuss the factors that determine whether loci connected to postzygotic reproductive barriers in the laboratory are inferred to reduce gene flow in nature. We synthesize data on the genetics of postzygotic isolation in house mice, one of the most intensively studied systems in speciation genetics. In a rare empirical comparison, we measure the correspondence of loci tied to postzygotic barriers via genetic mapping in the laboratory and loci at which gene flow is inhibited a..., , , # Data from: Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?

[https://doi.org/10.5061/dryad.m63xsj495](https://doi.org/10.5061/dryad.m63xsj495)

This dataset contains two types of data: 

1\) Summary of genomic regions associated with reproductive isolation in house mice. This data was individually compiled from publically available datasets from 36 studies and remapped to the mm10 reference genome using LiftOver. The archived dataset contains both the original and the mapped coordinates. 

2\) Results of permutation tests and rank sum tests looking for overlap within the house mouse data set. This was generated from tests comparing subsets of the house mouse dataset to each other. This data consists of CSV tables of p-values for overlap permutation tests, mean clines widths, and p-values for tests of cline width differences.

## Description of the data and file structure

The data are in two folders.

In \"*house_mouse_data*\", there are six fil...