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In Vitro Modeling of CD8 T Cell Exhaustion [ATAC-seq]

NIAID Data Ecosystem2026-05-02 收录

T细胞耗竭

ATAC-seq表观遗传学

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE211013 数据链接链接失效反馈

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资源简介：

ATAC-seq was used to study the chromatin landscape of Invitro CD8 T cell exhaustion cells Invitro generated CD8 Tcell subsets were assayed by ATACseq in replicates

应用场景：

创建时间：

2025-04-16

肿瘤免疫学

T细胞耗竭

We aimed to investigate the association between HPK1 expression and exhausted status of tumor. Overall design: Bulk RNA-seq was performed on fresh-frozen tissue samples of renal cell carcinoma.

NIAID Data Ecosystem60

scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

肿瘤免疫

T细胞耗竭

CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors

NIAID Data Ecosystem60

RNAseq of Wild Type and Prdm1/c-Maf cDKO CD8+ Tumor infiltrating lymphocytes isolated from B16F10 melanoma

肿瘤免疫微环境

T细胞耗竭

Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated co-inhibitory receptor expression on CD4+ T cells p

NIAID Data Ecosystem40

RNA-Seq analysis of P14 CD8+T cells in B16-GP tumors

肿瘤浸润T细胞

T细胞耗竭

CD8+ T cells play an important role in fighting against tumors. However, CD8+ T cells often become functionally impaired or “exhausted” in the tumor microenvironment. T cell exhaustion is a major hurd

NIAID Data Ecosystem60

Correlations of clinical parameters and T cell markers.

病毒感染免疫反应

T细胞耗竭

Spearman correlations of HCV-RNA and ALT with expression of activation and exhaustion markers and median expression of these markers in patients with F0–F2 versus F3–F4 fibrosis in all HCV-monoinfecte

Figshare2015-12-02 更新50

In Vitro Modeling of CD8 T Cell Exhaustion [ATAC-seq]

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