BIOGRID CURATED DATA FOR PHO81 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for PHO81 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress

PHO81（酿酒酵母S288c）的蛋白质-蛋白质、遗传和化学相互作用数据集，由BioGRID（https://thebiogrid.org）编纂；定义：周期依赖性激酶（CDK）抑制剂；调节Pho80p-Pho85p和Pcl7p-Pho85p周期-CDK复合物对磷酸水平的响应；对Pho80p-Pho85p的抑制活性需要由Vip1p生成的肌醇七磷酸酯（IP7）；在DNA复制压力下，相对核分布增加。