Supplementary Tables from Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas

ST1: Primer list; ST2: The most differentially expressed 401 transcripts (top 1%) in MADM tumors compared with normal brains; ST3: Upregulated 544 genes specifically in MADM tumors not in GL261; ST4: The mutational and expression status of 162 epigenome-associated genes in LGGs and GBMs; ST5: Significantly upregulated and downregulated genes by Ezh2 depletion; ST6: Representative genes with H3K4me3 alone, H3K27me3 alone or bivalent modifications in Ezh2 wild-type P8 precancerous cells and Ezh2 wild-type MADM tumor cells (top 50 genes with highest relative value); ST7: Gene ontology of upregulated genes by Ezh2 depletion.

ST1: 基因引物列表；ST2：与正常脑组织相比，在MADM肿瘤中表达差异最大的前401个转录本（占比最高1%）；ST3：在MADM肿瘤中特异性上调，但不在GL261细胞中表达的544个基因；ST4：在LGGs和GBMs中，162个表观遗传学相关基因的突变和表达状态；ST5：通过Ezh2耗竭显著上调和下调的基因；ST6：在Ezh2野生型P8前癌细胞和Ezh2野生型MADM肿瘤细胞中，仅H3K4me3修饰、仅H3K27me3修饰或双价修饰的代表性基因（相对值最高的前50个基因）；ST7：Ezh2耗竭上调基因的基因本体分析。