NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

To investigate the role of LDHA in myeloid cells in the response to pulmonary infection with Mycobacterium tuberculosis, we infected LDHAfl/fl:LysM+/- mice with Mtb-H37Rv via the aerosol route. We then performed gene expression profiling analysis using data obtained from RNA-seq of the lungs of these animals at 4 and 30 weeks post infection. Comparative gene expression profiling analysis of RNA-seq data for the lung tissue of LDHAfl/fl:LysM+/- (WT) and LDHAfl/fl:LysM+/- (KO) mice infected with Mycobacterium tuberculosis for 4 or 30 weeks.