PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane

At the Golgi membrane, phosphatidylinositide phosphatase SAC1 (SACM1L) dephosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI) but not as efficiently as phosphatidylinositol 4-phosphate (PI4P) dephosphorylation. No significant activity of this enzyme towards phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) was detected (Rohde et al. 2003).

在高尔基膜上，磷脂酰肌醇磷酸酶 SAC1（SACM1L）将磷脂酰肌醇3-磷酸（PI3P）去磷酸化成磷脂酰肌醇（PI），但其效率不及磷脂酰肌醇4-磷酸（PI4P）的去磷酸化过程。在检测中，未发现该酶对磷脂酰肌醇3,5-二磷酸（PI(3,5)P2）具有显著活性（Rohde 等人，2003年）。