Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788
收藏Protein Data Bank Japan2023-12-13 更新2026-03-21 收录
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Crystal structure of EGFR kinase domain T790M mutation in complex with AEE788 Descriptor: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR Authors: Yun, C.-H, Mengwasser, K.E, Toms, A.V, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J. Deposit date: 2007-07-01 Release date: 2008-01-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.05 Å) Cite: The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. Proc.Natl.Acad.Sci.USA, 105, 2008
创建时间：
2007-07-01
