TP53 family members bind the BAX promoter

TP53 (p53) binds the p53 response element in the promoter of the BAX gene (Miyashita and Reed 1995). TP53 family members TP63 (p63) and TP73 (p73) can also bind the BAX promoter. Complex formation between ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) and p53 family members TP53 (Samuels-Lev et al. 2001), TP63 or TP73 (Bergamaschi et al. 2004) enhances binding of p53 family members to the BAX promoter.

TP53（p53）结合于BAX基因启动子中的p53反应元件（Miyashita和Reed，1995年）。TP53家族成员TP63（p63）和TP73（p73）亦能结合BAX启动子。ASPP蛋白PPP1R13B（ASPP1）或TP53BP2（ASPP2）与p53家族成员TP53（Samuels-Lev等，2001年）、TP63或TP73（Bergamaschi等，2004年）形成的复合物，增强了p53家族成员对BAX启动子的结合。