Scalable pooled CRISPR screens with single cell chromatin accessibility profiling.
收藏NIAID Data Ecosystem2026-03-12 收录
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资源简介：
A scalable, cost-effective method that combines CRISPR perturbations with a single-cell indexing assay for transposase-accessible chromatin (CRISPR-sciATAC). This method links genome-wide chromatin accessibility to genetic perturbations through simultaneous capture of ATAC-seq fragments and CRISPR guide RNAs from single cells using a 96-well plate combinatorial indexing approach. Single cell ATAC-seq and CRISPR sgRNA capture for K562 cells and a mixture of NIH3T3 cells and HEK293T cells.
创建时间：
2020-11-09
