From Cyclic CF3‑ketimines to a Family of Trifluoromethylated Nazlinine and Trypargine Analogues
收藏数据链接：
官方服务：
资源简介：
An efficient (one- and two-step) synthesis of trifluoromethylated derivatives of the natural alkaloids nazlinine, trypargine, and homotrypargine was elaborated. Trifluoromethyl-substituted 5–7-membered cyclic imines were used as a masked carbonyl component in the Pictet–Spengler reaction with various tryptamines. As a result, this approach opens access to a family of alkaloid-like compounds bearing a CF3 group at position 1 of tetrahydro-β-carboline.
创建时间：
2016-09-12
