Expression data from abdominal aorta of cutaneous inflammation mice

Vascular disorder such as arteriosclerosis is one of the serious complications of chronic inflammatory skin diseases. We employed spontaneous dermatitis model mice overexpressing human caspase-1 in the epidermal keratinocyte (KCASP1Tg). GeneChip were performed to measure the changes in mRNA levels in the abdominal aorta. The mRNA was extracted from the abdominal aorta of 4-month-old KCASP1Tg and WT mice, and GeneChip analysis was performed. There were several upregulated genes in KCASP1Tg mice.