Precision-cut lung slices (PCLS) are increasingly utilized for ex-vivo disease modeling, but a high-resolution characterization of cellular-phenotype stability in PCLS has not been reported. Comparing
Investigation of hallmarks of COPD and CVD over an 8-month period in Apoe-/- mice exposed to conventional cigarette smoke or to the aerosol of a candidate MRTP, THS2.2. Evaluation of lung tissue struc
Genome editing has the potential to treat genetic diseases in a variety of tissues including the lung. We have previously developed and validated a dual adeno-associated virus (AAV) CRISPR platform th
Values are represented as mean ± S.E.M., where each measurement was performed 3 times on 12 animals/group. Bold numbers denoted by *represents a p value less than 0.05 compared to mock and room air tr
To address the need for human alveolar epithelial cell (AEC)-derived lines to more suitably model distal lung diseases, we have generated and characterized novel immortalized cell lines derived from h
